Chapters

Foreword by Editor-in-Chief 主编卷首语

Introduction/简介

Part 1 Comprehensive Drug Research

Optimized Expression,Preparation of Human Papillomavirus16 L2E7 Fusion Protein and Its Inhibitory Effect on Tumor Growth in Mice

Site-directed Mutagenesis of Human IL-29 and Antineoplastic Activity of the Recombinant Human IL-29 Variant

Expression,Purification of Recombinant Cationic Peptide AIK in Escherichia coli and Its Antitumor Activity

Apoptosis Induced by Transferring Cytosine Deaminase Suicide Gene into Kinds of Cancer Cells with Novel Polyamidoamine Dendrimers

Synthesis and Antiproliferative Evaluation of Steroidal Compounds Bearing Pyrazoline

Anti-tumor Effects and Mechanisms of the Fully Human Anti-EGFR Monoclonal Antibody(Ranti-HER)

Synthesis,Antitumor Activity and Molecular Docking of Quinolone Derivatives

Synthesis and Pharmacological Evaluation of Novel Cyclopropane-containing Semicarbazones Derivatives as Potential Anticonvulsant and Antitumor Agents

Design,Synthesis and Antiproliferative Activity Evaluation of EGFR Inhibitors Containing3-Hydroxy-4-pyridinone Fragment

Synthesis of Binuclear Copper(Ⅱ)Complex with Salicylaldehyde Thiosemicarbazone:Structure,Anticancer Properties and Anticancer Mechanism

Screening of Small Molecule Inhibitors for PLK1 PBD and Evaluation of Antitumor Activities

Anti-tumor Activity of HER-specific Peptide Vaccines-CKL9 and YL

In Vitro Metabolism and Drug-drug Interaction Potential of IG-105,a Novel Antimicrotubule Agent

Preliminary Study of Lipid Bilayer-coated Calcium Phosphate Nanoparticles as a Drug Carrier for Antitumor Drug

Design,Synthesis and Antitumor Activities of Cyclopropane Derivatives as Novel B-Raf Kinase Inhibitors

Synthesis and Antitumor Activity of Novel ALK and c-Met Kinase Inhibitors

Alkaloids from the Marine-derived Fungus Aspergillus fumigatus YK-7 and Their Antitumor Activities

Improved Synthesis of ALK Inhibitor Brigatinib

Synthesis and Antitumor Activity Evaluation of Imidazol-2-phenylamino-5-one Derivatives

Preparation and Evaluation of Anti-tumor Metastasis of Self-assembly Micelles Loaded with Indocyanine Green In Vitro

Design,Synthesis and Pharmacological Activities of 1,4-dien-3-one Benzamide Derivatives

Construction of HER2-specific CAR-T Cells and In Vitro Analysis of Their Activity to Suppress Tumor Cell Growth

Synthesis and Antitumor Activity of 4'-Demethylepipodophyllotoxin Aromatic Amide Derivatives

Isolation,Purification and Antitumor Activity of Bacillomycin D from Bacillus amyloliquefaciens Q-426

Preparation and Properties of Heparosan Polysaccharide-vitamin E Succinate Polymer Micelles

Impacts of Particle Shape on Cellular Uptake and Tumor Imaging Application of Ultra-p H Sensitive Micelles

An Efficient Synthesis of Antitumor Drug Cabazitaxel

Preparation of Thermoresponsive Micelles Loaded with Indocyanine Green and Doxorubicin for Combined Therapy in MCF-7 Cells

Synthesis and Antitumor Activity of δ-Lactam Compounds

Synthesis and Antitumor Activity Evaluation of Quinoline Derivatives Containing α,β-Enone Fragments

Design,Synthesis and Study of Anti-tumor Activity of Thiazolinone Urea Derivatives Bearing Aryloxypyridinone Fragments

Synthesis and Antitumor Activity of Arylaminopyrimidines Bearing Benzothiazine-1,1-dioxide Moiety as ALK Inhibitors

Design,Synthesis and Antitumor Activity Evaluation of Novel Steroidal Spirooxindole Derivatives Based on Pregnenolone

Design,Synthesis and Biological Activity of Twin Drugs of Antitumor Compound 990209

Synthesis and Antitumor Activity of Fluoroquinolone C-3 Arylidene Thiazolone Derivatives from Ciprofloxacin

Synthesis and Antitumor Activity In Vitro of Novel PARP-1 Inhibitors

Design,Synthesis and Biological Evaluation of Benzenesulfonamide-based Mutant IDH2 Inhibitors

Construction and Anti-tumor Efficacy of a Peptide Vaccine that Targets Calcium-binding Protein S100A9

Effect of Gap Junctions on Anti-proliferation Effect of mi R-124 and Its Mechanism

Design,Synthesis and Biological Evaluation of Diphenyl-based PD-L1 Inhibitors

Part 2 Mechanism Study

Construction of an Enediyne-energized Fusion Protein LDP-IGF-AE and Its Antitumor Activity on Non-small Cell Lung Cancer

Synergistic Anti-tumor Effects of Axitinib and Doxorubicin

Effect of Cx43 on Acquired Gefitinib-resistance Mechanisms in Human NSCLC HCC827 Cells

Proliferative Mechanism of Microrna-543 on Non-Small Cell Lung Cancer Cells by Molecular Biology

In Vitro Targeting Efficiency Evaluation of Reduction-responsive Co-loaded Doxorubicin/si RNA Nanoparticles

Liposomal Melatonin Dry Powder Inhalers for the Treatment of Primary Lung Cancer

Tumor Targeting and Suppression Effect in Nude Mice Induced by RGD and R8 Peptides Modified Liposomes Loading Ergosterol and Cisplatin

Construction and Anti-tumor Efficacy of a Pentameric Peptide Vaccine that Targets S100A8

A System Review:Comparison of Doxorubicin and Epirubicin Containing Regimens for Metastatic Breast Cancer

Reversal of Breast Cancer Multidrug Resistance In Vitro by Doxorubicin and Elacridar Co-delivery Nanoparticle

Antitumor Effect of Supernatant from Co-culture of Human Embryonic Stem Cells and Breast Cancer Cells on MDA-MB-231 Cells In Vitro

Endogenous Oxindole Isatin Induces Apoptosis of MCF-7 Breast Cancer Cells through a P53-mediated Mitochondrial Pathway

Olaparib Potentiates the Antitumor Effect of Taxol on4T1 Breast Cancer

Important Role of ELMO1 in Invasion and Migration of Breast Cancer Cells Induced by IL-8

Mechanism Research of Apatinib-treated Breast Cancer Based on Network Pharmacology

Treatment of Triple Negative Breast Cancer Cells with Combination of m TOR1/2 Inhibitor AZD8055 and MEK1/2 Inhibitor PD0325901

Study of Cisplatin Aggravating DNA Damage and Causing a High Apoptosis Rate on Breast Cancer MCF-7 Cells

Establishment of Breast Cancer Cells with Stable Expression of ST3GalⅢ Gene RNA Interference via Lentivirus Vector

Relationship between CMPK1 Protein and ADM Caused Multidrug Resistance

Matrix Stiffness Regulates Cell Uptake of Nanoparticles in2D and3D Cultures of Breast Cancer Cells

Co-culture of Human Breast Adenocarcinoma Cells and Human Umbilical Vein Endothelial Cells to Mimic In Vivo Tumor Microenvironment

A UPLC-MS/MS Method for Quantification of a Novel Doxorubicin Conjugation Prodrug in Tumor Cells

In Vitro Anticancer Effect of Combretastatin A4 Liposomes in Destruction of Vascular Mimicry in Triple-negative Breast Cancer Cells

Reversal Effect and Mechanism of15-PGHD Induction Drugs on the Multidrug Resistance of Human Breast Cancer Cell Line MCF-7/ADR

Reverse Effect of mi R-186-5p on Adriamycin Resistance of Breast Cancer Cells through Targeting RAB2A and Its Mechanism

Mechanisms of Doxorubicin Resistance of Breast Cancer MCF-7 Cells Mediated by Exosomes

Inhibition of Proliferation of Breast Cancer Cells by Down-regulation of Cyclin D1 and Survivin Protein Expression by ERK Inhibitor U0126

Norepinephrine Increases Risk of Breast Cancer in Depressed Women

Anti-tumor Effect and Impact on Tumor Immune Microenvironment of Tumor-targeted Salmonella VNP20009

Apoptosis-inducing Effect of5-Fluorouracil Combined with Resveratrol on Tumor Cells In Vitro and In Vivo

Mechanism of IL-1βEnhancing Blood-brain Tumor Barrier Permeability

Identification of In Vivo Activity of Defactinib-microcrystal on Hepatocellular Carcinoma Cells Using Positron Emission Computed Tomography

Expression and Clinical Significance of CXCL14 and EGFR in Human Gastric Cancer

Single Nucleotide Polymorphisms Analysis of Drug Related Genes in Digestive Tract Cancer

Label-free Quantitative Proteomic Analysis of Acquired Herceptin Resistance in Gastric Cancer Cells

Preliminary Study of Peptide from Periplaneta americana on Antitumor Immunity in L1210-bearing Mice

Part 3 Clinical Study

Effect of Family History of Cancer on Clinical Features and Prognostic Factors of Patients with Nasopharyngeal Carcinoma

Relationship between MAPK1 Gene Polymorphism and Gefitinib Hepatotoxicity in NSCLC Patients with Activating EGFR Mutations

Comparative Analysis of Immediate Breast Reconstruction after Skin-sparing Mastectomy and Modified Radical Mastectomy in Young Breast Cancer Patients

Adverse Reactions of Chemoradiotherapy with Docetaxel after Modified Radical Mastectomy in Locally Advanced Breast Cancer

Clinical Value of Combining Indocyanine Green Fluorescence Navigation with Methylene Blue in Sentinel Lymph Node Biopsy in Patients with Breast Cancer

Diagnosis Value of Ultrasound-guided Core-needle Biopsy in Breast Masses under BI-RADS Categories 4A to 4C

Effectiveness of Computer-based Monitoring System for Patients with Breast Cancer Receiving Adjuvant Hormonal Therapy

A Cost-effectiveness Analysis of Adjuvant Trastuzumab Regimens in HER2-positive Early Breast Cancer

Effect of Everolimus on the Treatment of1 Case of Refractory Advanced Breast Cancer with PI3K/AKT/m TOR Pathway Mutations

Design and Clinical Application of Rehabilitation VR System for Breast Cancer Patients

Development of Continuing Nursing Evaluation System for Patients with Breast Cancer

Consistency Study of Self-reports and Nursing Notes in Adjuvant Chemotherapy-related Side Effects among Patients with Breast Cancer

Application and Effect of Virtual Cognitive Rehabilitation Training in Breast Cancer Patients with Cognitive Impairment after Chemotherapy

A Trajectory Study of Sleep and Related Symptoms in Breast Cancer Patients Based on Ecological Momentary Assessment

Ultrasound-guided Percutaneous Nephrostomy for the Treatment of Cancer-related Hydronephrosis:A Report of 289 Cases

Perioperative Nursing of Three Patients Undergoing Resection with Tumors Involving Intra-and Extra-cranial Regions and Anterolateral Femoral Skin Flap Repair

Establishment and Application of Respiratory Function Training Program for Patients with Postoperative Dysphagia after Posterior Fossa Tumor Surgery

Microsurgical Treatment of Spinal Cord Congenital Tumors

Changes of Circulating Tumor Cells in Locally Advanced Esophageal Squamous Cell Carcinoma Patients Treated with Concurrent Chemoradiotherapy

A Comparative Analysis of the Incidence Rates of Esophageal Cancer and Upper Gastrointestinal Cancer in Cixian County,Hebei Province,China

Analysis of Short-and Long-term Outcomes after Esophagectomy in Elderly Cancer Patients

Efficacy of S-1 Combined with Cisplatin as First-line Chemotherapy for Advanced AFP Positive Gastric Cancer

Association of Serum PGE-2 and VEGF Levels and the Expression of VEGF in Gastric Cancer Tissue and Clinicopathological Features of Gastric Carcinoma Patients with Hyperlipidemia

Correlation between Preoperative NLR,PLR,and RDW and Clinical Pathological Parameters in Gastric Cancer Patients

Association of Preoperative Platelet Distribution Width with Clinicopathologic Features and Prognosis of Gastric Cancer Patients

Analysis of Clinical Adverse Reactions of Apatinib for the Treatment of Malignant Tumors

Analysis of Clinical Characteristics and Prognosis of63 Cases of Pancreatic Neuroendocrine Tumor

Clinical Analysis of Rituximab-induced Interstitial Pneumonia

Part 4 Nursing Research

Effects of Different Gargling Methods of Sodium Bicarbonate on Oral pH Values in Children with Malignant Tumors Undergoing Chemotherapy

Clinical Application of Located Subcutaneous Jugular Vein Inserted Central Catheter in Cancer Patients

A Qualitative Research on Role Cognition and Experience among Peer Supporters of Gynaecological Cancer Patients